Hormonal Regulation of Sertoli Cell Micro-RNAs at Spermiation
نویسندگان
چکیده
منابع مشابه
Hormonal and cellular regulation of Sertoli cell anti-Müllerian hormone production in the postnatal mouse.
Anti-Müllerian hormone (AMH) is secreted by immature testicular Sertoli cells. Clinical studies have demonstrated a negative correlation between serum AMH and testosterone in puberty but not in the neonatal period. We investigated AMH regulation using mouse models mimicking physiopathological situations observed in humans. In normal mice, intratesticular, not serum, testosterone repressed AMH s...
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The Sertoli cell is a highly differentiated somatic cell in the seminiferous epithelium of the testis. This cell is of prime importance for both testicular development and spermatogenesis. Sertoli cells proliferate up to the start of puberty and, due to their nursing functions, the final Sertoli cell number is well correlated to the amount of germ cells produced by the adult testis. The physiol...
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First miRNAs were described in a flatworm species C. elegans, which led to an understanding of their important regulatory role in cell differentiation (Lee et al., 1993; Wightmanet al., 1993). Another critical step was the discovery of the second miRNA named let-7, which is a product of expression of a heterochronic switch gene in C. elegans (Reinhart et al., 2000). Loss of let-7 gene activity ...
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Unwanted childlessness affects approximately one in six couples worldwide. According to the World Health Organization, in nearly 40% of cases the cause can be attributed to the female, in 20% to the male, in 25% to both, and in 15% the cause remains unknown. The incidence of male factor infertility in the general population is approximately 7%. The majority of these men experience irreversible ...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2011
ISSN: 0013-7227,1945-7170
DOI: 10.1210/en.2010-1341